Resistance to cisplatin is the main cause Gift Set of treatment failure in lung adenocarcinoma.Drug-tolerant-persister (DTP) cells are responsible for intrinsic resistance, since they survive the initial cycles of treatment, representing a reservoir for the emergence of clones that display acquired resistance.Although the molecular mechanisms of DT

Cyanobacteria, microorganisms performing oxygenic photosynthesis, must adapt their metabolic processes to environmental challenges such as day and night changes.PipX, a unique regulatory protein from cyanobacteria, provides a mechanistic link between the signalling protein PII, a widely conserved (in Pilsner Beer Glasses bacteria and plants) transd

Demand for cancer genetic counseling has grown rapidly in recent years as germline genomic information has become increasingly incorporated into cancer care and the field has entered the public consciousness through high-profile celebrity publications.Increased demand and existing variability in the availability of trained cancer genetics clinician

Because the glucocorticosteroid receptor seems to be uniform in the human body, there is currently no support for a possibility of separating the therapeutic and adverse glucocorticosteroid actions at the receptor level.However, based on a new generation of glucocorticosteroids characterized by a high first pass metabolism in the liver, it seems po

ABSTRACT Introduction and objectives: Performing cardiac catheterization can be challenging regarding the management of congenital heart disease.Therefore, the use of risk scoring or grading systems can help us plan the procedure.Back in 2015, the Congenital Cardiac Interventional Study Consortium developed and validated a system called CRISP (Cath